李娜+杨丰文+陆中英+张冬+刘春香+郑文科
[摘要] 体系点评蓝芩口服液医治缓慢咽炎的作用和安全性。计算机检索PubMed，Embase，Cochrane Library，CBM，CNKI，VIP，万方科技数据库，搜集蓝芩口服液医治缓慢咽炎的随机对照研讨，检索时限均为从建库至2017年3月，由2名研讨者依照归入和扫除规范独立进行文献挑选、材料提取，用Cochrane偏倚点评手册进行质量点评并穿插核对。选用RveMan.5.3软件进行数据剖析。共归入13个随机对照实验，合计1 642例缓慢咽炎患者。Meta剖析成果显现： ①有效率：蓝芩口服液医治组优于对照组（惯例医治或其他药物医治）；②IL-2：蓝芩口服液医治组优于对照组（MD及95% CI，2.20[1.91，2.48]，P<0.000 01）；③TNF-α：蓝芩口服液医治组优于对照组（MD及95%CI，0.75[0.60，0.90]，P<0.000 01）；④不良反应：无安全性信息陈述。根据现有临床根据，蓝芩口服液医治缓慢咽炎的有效率优于惯例医治或其他药物医治。但由于归入研讨的方法学质量遍及较低，需求严厉方法学规划和质量操控的临床研讨供给高质量的根据。
[关键词] 蓝芩口服液；缓慢咽炎；随机对照实验；体系点评；Meta剖析
Lanqin oral liquid for the treatment of chronic pharyngitis：
systematic review and Meta-analysis of randomized clinical trials
LI Na1，YANG Feng-wen1，LU Zhong-ying1，ZHANG Dong2，LIU Chun-xiang2，ZHENG Wen-ke2
（1. Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China；
2. Center for Evidence-Based Medicine，Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China）
[Abstract] To systematically assess the effectiveness and safety of lanqin oral liquid for the treatment of chronic pharyngitis. Databases including PubMed，Embase，The Cochrane Library，SinoMed，CNKI，VIP and Wanfang Data were electronically searched in March 2017 for randomized controlled trials（RCTs） on Lanqin oral liquid for the treatment of chronic pharyngitis. Two authors independently screened literature，extracted data，and assessed the risk of bias of included studies. Then，meta-analysis was performed by RevMan 5.3 software. Thirteen RCTs were included with a total of 1 642 patients. The results of meta-analysis showed that the efficiency of lanqin oral liquid were significantly higher than those of conventional therapy or other treatments；Besides，lanqin oral liquid could significantly increase the amount of IL-2 further more，lanqin oral liquid could significantly reduce the amount of TNF-α. Safety of lanqin oral liquid was not concerned by any RCT. Current evidence indicates that the efficiency of lanqin oral liquid was better than conventional therapy or other treatments. Due to the poor quality of the included studies，the above conclusion should be verified by more RCTs of high quality.
[Key words] Lanqin oral liquid；chronic pharyngitis；randomized controlled trial；dystematic review；Meta-analysis
缓慢咽炎是指咽喉部黏膜的缓慢炎癥，是临床上常见病症，具有病程长、重复发生等特色，主要是因细菌、病毒等要素长时间影响所造成的，多发于成年人[1]。缓慢咽炎患者的临床表现主要有咽部痛苦、有异物感、发痒及咳嗽等，尤其是在晨起刷牙时会呈现反射性的厌恶、欲吐等现象，影响患者及其家族的日子质量[1]。现在蓝芩口服液医治缓慢咽炎的临床研讨较多，但缺少体系的剖析和点评。本研讨旨在对蓝芩口服液医治缓慢咽炎的临床作用进行体系点评，以期为蓝芩口服液在临床的正确使用供给根据。
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